ACACIA RESEARCH CENTER

Breaking barriers and discovering the most effective treatments for mental illness.

Acacia Research Center results are inspiring, life-changing, and a reminder that the pursuit of better mental health care should never be stagnant. There is so much to discover; we have a lot of work to do.

brain mri
Acacia Research Center Loog

What we do

In-House Research

The Acacia Research Center (ARC) is dedicated to advancing neuroscience and revolutionizing neuromodulation treatment. Our in-house research team analyzes real-world treatment outcomes data to fully understand the efficacy of novel TMS approaches. These findings help inform and guide decision-making, enabling continuous optimization of personalized treatment protocols

Sponsors & Partnerships

At ARC, we collaborate with industry and academic partners to conduct pioneering clinical trials. We provide comprehensive services, including project management and FDA-level inspection support. Partnering with us saves sponsors valuable time due to our well-equipped infrastructure and certified staff ensuring strict regulatory compliance and participant safety.

Publishing Research

Acacia team members have a strong track record of publishing in the fields of neuropsychiatry, brain imaging, and neuromodulation. We've disseminated our research through peer-reviewed articles, abstracts, and presentations at international conferences, contributing to the advancement of healthcare knowledge and the improvement of patient care.

FEATURED RESEARCH PROJECT

Clinical Trial for Anxiety

Anxiety is the most common mental illness in the world, affecting an estimated 40 million people in the United States each year. This study is designed to study whether low-intensity ultrasound can temporarily alter self-reported anxiety and brain activity related to emotional processing.

PARTICIPANT REQUIREMENTS

  • Between 18-80 years of age

  • Currently diagnosed with Generalized Anxiety Disorder, panic disorder, or Social Anxiety Disorder within the past year with or without Major Depressive Disorder

There are other requirements for participation in the study. The study doctor will explain these to you

If you are interested in learning more about this trial, please contact us at [email protected].

FEATURED RESEARCH PROJECT

Magnus SAINT ™

Acacia Clinics is the most experienced provider of SAINT® Therapy and we’ve been there since the beginning. Since 2021, our doctors, technicians, and staff have been conducting research trials with SAINT®.

PARTICIPANT REQUIREMENTS

  • At least 18 years of age

  • Currently diagnosed with major depression and failed to achieve satisfactory improvement from prior antidepressant medication in the current episode

  • Eligible for an MRI Scan

If you are interested in learning more about this trial, please contact us at [email protected]

RESEARCH TEAM

Acacia’s research leadership team is at the forefront of TMS and neuroscientific research, leading and co-authoring dozens of renowned research publications.

Danielle DeSouza, PhD
VP of Research

Erica Nakano
Clinical Research Associate (CRA)
Research team member profile, Vivian Hoang

Laura Schulze, PhD
Scientist

Vivian Hoang
Clinical Research Coordinator (CRC)

Research team member profile, Erica Nakano
Research team member profile, Danielle DeSouza

Select Published Research

Research contributed by an Acacia Researcher as a first or co-author.

  • Accelerated Intermittent-Theta Burst Stimulation for the Treatment of Adolescent Depression: A Case Series

    Depression / Published 2023

    Nakano, E., Sedaros, P., Siddiqi, S., Meng, N., DeSouza, D., & Carreon, D. (2023)

    Read Research

  • Accelerated Theta-Burst Stimulation Using Individualized fMRI-based Targets in Adolescents with Depression

    Depression / Published 2023

    Nakano, E., Sedaros, P., Hoang, V., Pi, J., Marco, J., Shankar, S., Pai, G., Luna, A., Siddiqi, S., Meng, N., DeSouza, D., & Carreon, D.

    Read Research

  • Deep TMS H1 Coil Treatment for Depression: Results from a Large Post Marketing Data Analysis

    Depression / Published 2023

    Tendler, A., Goerigk, S., Zibman, S., Ouaknine, S., Harmelech, T., Pell, G. S., Zangen, A., Harvey, S. A., Grammer, G., Stehberg, J., Adefolarin, O., Muir, O., MacMillan, C., Ghelber, D., Duffy, W., Mania, I., Faruqui, Z., Munasifi, F., Antin, T., … Roth, Y.

    Read Research

  • Stanford Neuromodulation Therapy (SNT): A Double-Blind Randomized Controlled Trial

    Depression / Published 2022

    Cole, E. J., Phillips, A. L., Bentzley, B. S., Stimpson, K. H., Nejad, R., Barmak, F., Veerapal, C., Khan, N., Cherian, K., Felber, E., Brown, R., Choi, E., King, S., Pankow, H., Bishop, J. H., Azeez, A., Coetzee, J., Rapier, R., Odenwald, N., Carreon, D., … Williams, N. R.

    Read Research

  • Deep TMS for Major Depression, Interim Post-Marketing Analysis of 1040 Patients

    Depression / Published 2020

    Harvey, S. A., Tendler, A., DeLuca, M., Stehberg, J., Naimark, R., Schmidt, D., Muir, O., McMillan, C., Shakir, S., Antin, T., Ghelber, D., Duffy, W., Lender, N., Goodman, M., Isserles, M., Melman, K., Cabrera, J., Jr., Munasifi, F. A., Jones, D., … Roth, Y.

    Read Research

  • Cortical Thickness Changes Following Accelerated Neuromodulation Therapy for Treatment-Resistant Depression Predict Depression Scores at One-Month

    Depression / Published 2021

    DeSouza, D., Bentzley, B., Cole, E., Phillips, A., Nejad, R., Stimpson, K., Schatzberg, A., Sudheimer, K., & Williams, N.

    Read Research